Perfenazin hemmer omdannelsen fra kodein til den aktive metabolitten morfin by way of CYP2D6 og vil dermed kunne gi nedsatt analgetisk effekt av kodein.Dying as well as prerequisite of the liver transplant may additionally happen. Metabolism via the CYP2E1 pathway releases a toxic acetaminophen metabolite often known as N-acetyl-p-benzoquinoneimine

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